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This could be true, Eissenberg stated, as long as the e-cigarette device and its liquid are not designed in a way that would deliver excessive levels of the addictive substance or other dangerous chemicals to the user. However, restrictions dictating safer design may only occur through federal regulation since product developers may not be inclined to self-impose such regulations. With this novel nicotine mathematical model, researchers will now be able to predict with a great deal of accuracy how much nicotine will be delivered to an e-cigarette user before a device is even designed. These predictions will further enable researchers like Eissenberg and his colleagues to inform federal regulators about evidence-based recommendations on e-cigarette design restrictions that could potentially avoid a serious public health disaster as more people turn to e-cigarettes as an alternative nicotine delivery method. This model also sets the framework for a clinical trial that has just opened at the VCU CSTP as well as Penn State Universitys Tobacco Center of Regulatory Science in Hershey, Pa., that will evaluate novel tobacco products, including e-cigarettes, on health indicators and cigarette smoking behavior in people who are currently smoking tobacco cigarettes and who are interested in reducing their cigarette use. Eissenberg collaborated to develop the aerosol nicotine exposure model with lead author Alan Shihadeh, Sc.D. director of Project 1, Analytic Lab Methods for Modified Risk Tobacco Product Evaluation (MRTP), member of the Executive Leadership Committee at the VCU Center for the Study of Tobacco Products (CSTP) and Professor of Mechanical Engineering at the American University of Beirut (AUB); Soha Talih, Ph.D., research scientist at the VCU CSTP and research scientist at the Department click rainbow of Mechanical Engineering at the AUB; Rola Salman, B.S. analytical chemist at the VCU CSTP and manager of the Aerosol Research Lab at the AUB; Zainab Balhas, member of the Project 1 team at the VCU CSTP and graduate student in the Mechanical Engineering Department at the AUB; Nareg Karaoghlanian, B.E.,member of the investigative team of Project 1 at the VCU CSTP andresearch engineer at the AUB Mechanical Engineering Department; Ahmad El Hellani, Ph.D., member of the investigative team of Project 1 at the VCU CSTP and postdoctoral associate in the Chemistry and Mechanical Engineering Departments at AUB; Rima Baalbaki, M.S., research assistant at the VCU CSTP and in the Department of Engineering at the AUB; and Najat Saliba, Ph.D., Professor of Chemistry at the AUB. Funding for this research was supported by the National Institute on Drug Abuse of the National Institutes of Health (NIH) grant P50 DA036105, the Center for Tobacco Products of the U.S. Food and Drug Administration and, in part, by VCU Massey Cancer Centers NIH-NCI Cancer Center Support Grant P30 CA016059. The VCU Center for the Study of Tobacco Products is a World Health Organization Collaborating Center.
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